The body said in a document released at its annual conference that henceforth, any doctor who prescribed excessive antibiotics could be disciplined and possibly banned from practice.
The Institute said the new guidelines aimed at encouraging doctors and health professionals towards sensible use of antibiotics, to help tackle the rise in resistance to the drug.
NICE said it was unfortunate that doctors do not adhere to existing guidance on antibiotics prescription.
The organisation said if successfully implemented, the new guidance could help reduce antibiotic prescribing by 25 per cent, accounting for around 10 million fewer antibiotic prescriptions a year.
“The more antibiotics are used the less effective they become, because overuse gives resistant bacteria a greater chance to survive and spread.
“The problem of antibiotic resistance is compounded by the fact that the discovery of new antibiotics is at an all-time low,’’ it said.
It said a multidisciplinary antimicrobial stewardship teams would be setup to review prescribing and resistance data frequently and feed information back to doctors and other prescribers.